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Physical inactivity impairs glucose levels leading to diabetes



Posted On: Aug. 25, 2011

Washington, August 24 (ANI): With the increased number of people being diagnosed with diabetes, researchers have focused on discovering why the prevalence of the disease is increasing.

John Thyfault, an assistant professor in MU's departments of Nutrition and Exercise Physiology and Internal Medicine, had found that ceasing regular physical activity impairs glycemic control (control of blood sugar levels), suggesting that inactivity may play a key role in the development of type 2 diabetes.

"We now have evidence that physical activity is an important part of the daily maintenance of glucose levels," said Thyfault.

"Even in the short term, reducing daily activity and ceasing regular exercise causes acute changes in the body associated with diabetes that can occur before weight gain and the development of obesity," added Thyfault.

Thyfault studied the relationship between low levels of physical activity and elevated levels of postprandial glucose (PPG), or the spikes in blood sugar that occur after a meal.

PPG is a risk factor for the development of type 2 diabetes and has been associated with increased incidences of cardiovascular disease and death.

Thyfault found that when healthy individuals reduced their physical activity by about half for three days, their PPG responses to meals doubled.

"A single bout of moderate exercise can improve the way the body maintains glucose homeostasis (blood glucose regulation) and reduce PPG, but becoming inactive for a short period of time quickly disrupts glucose homeostasis," said Thyfault.

"This study shows that physical activity directly impacts health issues that are preventable," added Thyfault.

The study will be published in Medicine and Science in Sports and Exercise. (ANI)

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